Supplemental Movie from Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution
Year: 2023
Type: supplementary-materials
Abstract: Simultaneous video of four simulations of tumor growth with accompanying phenotypic "flow" diagram, Top left: untreated; top right: low dose, early; bottom left: high dose, late; bottom right: low dose, late. The appearance of the white box in each of the treated windows indicates when the buffer treatment was applied (all vessels secrete buffer). In the phenotype flow plot, the cyan dot shows the median phenotype of all tumor cells, black points indicate distribution of phenotypes present in the tumor at each time point. The simulations show that the buffer therapy reverses the evolution towards the glycolytic, acid-resistant phenotype, with early or high dose having the stronger effect. A late, low dose does have an effect on the progression, but the invasive phenotype persists despite the therapy and will eventually dominate.
Language: English
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4362014476