Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Year: 2023
Type: other
Abstract: Supplemental figures include the RSPO gene expression analysis for CRC models, the in vitro testing of anti-RSPO antibodies on RSPO-negative tumors, the IHC analysis of anti-RSPO3+chemo-treated ovarian tumors, the LGR, ZNRF3, and RNF43 gene expression profile in therapy responsive and non-responsive PDXs, the in vivo resistance of RSPO-negative tumors to RSPO blockade, the analysis of CSC frequency in anti-RSPO3-treated NSCL and pancreatic PDXs, and the IHC detection of CD44 in anti-RSPO3-treated CRC tumors.
Authors: Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cristina Dee-Hoskins, Shirley Ma, Marcus M. Fischer, Jalpa Shah, Jie Wei, May Ji, Andrew Lam, Michelle Stroud, Wan-Ching Yen, Pete Yeung, Belinda Cancilla, Gilbert O'Young, Min Wang, Ann M. Kapoun, John Lewicki, Timothy Hoey, Austin Gurney
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362016872