Neurocognitive test performance following cancer among middle‐aged and older adults in the Hispanic Community Health Study/Study of Latinos ( HCHS / SOL ) and the SOL‐Investigation of Neurocognitive Aging Ancillary Study
Year: 2023
Type: article
Abstract: BACKGROUND: Cancer patients and survivors often experience acute cognitive impairments; however, the long-term cognitive impact remains unclear particularly among Hispanics/Latinos. We examined the association between cancer history and neurocognitive test performance among middle-aged and older Hispanic/Latinos. METHODS: Participants included 9639 Hispanic/Latino adults from the community-based and prospective Hispanic Community Health Study/Study of Latinos. At baseline (2008-2011; V1), participants self-reported their cancer history. At V1 and again at a 7-year follow-up (2015-2018; V2), trained technicians administered neurocognitive tests including the Brief-Spanish English Verbal Learning Test (B-SEVLT), Word Fluency Test (WF), and Digit Symbol Substitution Test (DSS). We used survey linear regression to estimate the overall, sex-specific, and cancer site-specific [i.e., cervix, breast, uterus, and prostate] adjusted associations between cancer history and neurocognitive test performance at V1 and changes from V1 to V2. RESULTS: At V1, a history of cancer (6.4%) versus no history of cancer (93.6%) was associated with higher WF scores (β = 0.14, SE = 0.06; p = 0.03) and global cognition (β = 0.09, SE = 0.04; p = 0.04). Among women, a history of cervical cancer predicted decreases in SEVLT-Recall scores (β = -0.31, SE = 0.13; p = 0.02) from V1 to V2, and among men, a history of prostate cancer was associated with higher V1 WF scores (β = 0.29, SE = 0.12; p = 0.02) and predicted increases in SEVLT-Sum (β = 0.46, SE = 0.22; p = 0.04) from V1 to V2. CONCLUSION: Among women, a history of cervical cancer was associated with 7-year memory decline, which may reflect the impacts of systemic cancer therapies. Among men, however, a history of prostate cancer was associated with improvements in cognitive performance, perhaps due in part to engaging in health promoting behaviors following cancer.
Source: Cancer Medicine
DOI: 10.1002/cam4.5863
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,070
Funders: University of Miami, Northwestern University, San Diego State University, Division of Cancer Prevention, National Cancer Institute, Institut National Du Cancer, National Institutes of Health, Gillings School of Public Health, University of California, San Diego, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute
Awards: G1075639496, G1081972346, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G1556411293, G1587824183, G1666450717, G207167272, G2135211244, G213973861, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2528054427, G2575730562, G2644289446, G2941511437, G2970637568, G304251076, Hispanic Community Health Study, G3677686024, G3722034730, G3789696831, G3952816605, Study of Latinos Investigation of Neurocognitive Aging 2, G4323189256, Hispanic Community Health Study, G4552920371, G4989378220, G5001948697, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G5545397803, G5569137227, G5878028785, G5906656038, G5935820280, G6075306088, G6585687856, G6744188800, G6840272165, G7057037114, 1/2 SDSU/UCSD Cancer Center Comprehensive Partnership, G7278742613, G7393220086, G7400840618, G7513901258, G7633706493, G7644897314, 2/2 SDSU/UCSD Cancer Center Comprehensive Partnership, Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women's Healthy Eating and Living (WHEL) Study, G820454163, G8904081916, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease, San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR)
OpenAlex ID: W4362194829