Supplementary Figure 3 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Year: 2023
Type: supplementary-materials
Abstract: PDF file, 330K, A. rhCCN6 protein rescues the upregulation of P-p38 and the invasive phenotype due to CCN6 KD in HME cells. B. p38 kinase activity inhibitor SB203580 reversed the invasive phenotype of CCN6 KD HME cells. C. Inhibition of p38 kinase by 20 �M SB203850 or 10 �M SB202190 is sufficient to reduce invasion of SUM149 IBC cell line and aggressive MDA-MB-231 breast cancer cells.
Authors: Anupama Pal, Wei Huang, Xin Li, Kathy A. Toy, Zaneta Nikolovska-Coleska, Celina G. Kleer
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362241652