Supplemental Figure S1 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure S1. Top candidates are enriched in known protein-protein interactions as determined by IPA. This network was generated through an IPA core analysis of genes scoring p {less than or equal to} 0.001 by RSA. The analysis considered only known direct relationships between genes, and used the ~7,000 genes represented in the screen as background. Genes scoring p {less than or equal to} 0.001 are highlighted in red. The network was the top scoring IPA network (score = 44).
Authors: Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas D. Pfister, Philip M. Reaper, Christopher S. Barnes, Julie Jones, Peter Charlton, John R. Pollard, Joel Morris, James H. Doroshow, Yves Pommier
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362242162