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Supplemental Figures S1-S5 from Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling

Year: 2023

Type: supplementary-materials

Abstract: Representative time plot of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) measurements & migratory and AMPK phosphorylation response to CXCL12 of patient-derived pancreatic cancer cells ; Characterization of murine-derived pancreatic cancer cells ; CXCL12-induced AMPK activity is Gαi and CXCR4 dependent ; CXCL12-induced AMPK activity is calcium dependent ; Cytostatic CXCL12 stimulates MYPT1 phosphorylation at T853 .

DOI: 10.1158/0008-5472.22405089

Authors: Ishan Roy, Donna M. McAllister, Egal Gorse, Kate Dixon, Clinton T. Piper, Noah P. Zimmerman, Anthony E. Getschman, Susan Tsai, Dannielle D. Engle, Douglas B. Evans, Brian F. Volkman, Balaraman Kalyanaraman, Michael B. Dwinell

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362291326

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