Supplementary Figures S1-S6 from Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b–Mediated Malignant Progression
Year: 2023
Type: supplementary-materials
Abstract: hASC characterization (S1); Co-culture of immature adipocytes with mammary epithelial cells increases pro-inflammatory cytokine expression (S2); Immature adipocyte or cytokine exposure increases abundance of sphere and colony forming cells without changing global cell proliferation (S3); Immature adipocyte or cytokine exposure increases matrigel invasion in vitro and tumor formation, vasculogenesis and metastasis in vivo (S4); Src mediates cytokine effects via ES-TF upregulation affecting soft agar colony growth but not cell cycle progression (S5); Cytokine-mediated increase in sphere formation is Sox2-dependent and miR302b upregulation drives further c-MYC and SOX2 gene expression (S6).
Authors: Manuel Picon-Ruiz, Chendong Pan, Katherine Drews-Elger, Kibeom Jang, Alexandra H. Besser, Dekuang Zhao, Cynthia Morata-Tarifa, Minsoon Kim, Tan A. Ince, Diana J. Azzam, Seth A. Wander, Bin Wang, Burcu Ergonul, Ram H. Datar, Richard J. Cote, Guy A. Howard, Dorraya El-Ashry, Pablo Torné-Poyatos, Juan A. Marchal, Joyce M. Slingerland
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362299463