Work

Supplemental Figures S1-S5 from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer

Year: 2023

Type: supplementary-materials

Abstract: Responsiveness of different molecular subtypes breast cancer cell lines to TGFÎ² as measured by PAI-1 expression levels (S1); TGFÎ²ï�¢and MYC knockdown inhibit cell proliferation (S2); MYC reduction potentiates TGFÎ² induced invasive phenotype in SUM149 cells (S3); Pharmacological inhibition of SRC blocks the effect of TGFÎ² treatment on increased levels of integrin Î±vÎ²3 (S4); Pharmacological inhibition of MYC mimics the effect of MYC knockdown on integrin Î±vÎ²3 levels, in a dose dependent manner (S5).

DOI: 10.1158/0008-5472.22411868

Authors: Magdalena A. Cichon, Megan E. Moruzzi, Tiziana A. Shqau, Erin Miller, Christine Mehner, Stephen P. Ethier, John A. Copland, Evette S. Radisky, Derek C. Radisky

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362320282

Cites:

Cited by:

Related to: 10