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Supplemental Figure 5 TRIM3 effects on Importinβ1 nuclear localization and NICD binding. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport

Year: 2023

Type: supplementary-materials

Abstract: (A,B,C,D) N08-74 VC and 13113 VC both show more Importinβ1 nuclear localization than TRIM3 expressing N08-74 and 13113 cells, respectively. (E,F,G,H) NICD binds with Importin beta to a greater extent in TRIM3 null N08-74 and 13113 as compared to TRIM3 expressing N08-74 and 13113 cells, respectively. Scale bar: 5um.

DOI: 10.1158/0008-5472.22410855

Authors: Subhas Mukherjee, Carol Tucker-Burden, Changming Zhang, Kenneth Moberg, Renee Read, Costas Hadjipanayis, Daniel J. Brat

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362325911

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