Supplementary Figures and Methods from HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figures (Fig.S1-S4) and Supplementary Materials and Methods. Supplementary Figure S1. Loss of Hace1 results in increased lung tumorigenesis independent of RIPK3. Supplementary Figure S2. Analysis of RAC, NRF2 and 4HNE expression. Supplementary Figure S3. Analysis of tumor microenvironment. Supplementary Figure S4. Treatment of KRasG12D;Hace1-/- mice with a ROS scavenger diminishes lung tumorigenesis and Hace1-deficient cells are sensitive to exogenous induction of oxidative stress.
Authors: Melanie Kogler, Luigi Tortola, Gian Luca Negri, Alexandra Leopoldi, Amal M. El-Naggar, Stefan Mereiter, Carlos Gomez-Diaz, Roberto Nitsch, Davide Tortora, Anoop M. Kavirayani, Bianca V. Gapp, Shuan Rao, Iris Uribesalgo, David Hoffmann, Domagoj Cikes, Maria Novatchkova, David A. Williams, Jeffrey M. Trent, Fumiyo Ikeda, Mads Daugaard, Astrid Hagelkruys, Poul H. Sorensen, Josef M. Penninger
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362364684