Supplementary Data from Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1. Chromosome missegregation in FTSECs by pharmacologic inhibition of Mps1 and CENP-E (relates to Figures 1 and 2); Supplementary Figure S2. Comparisons of monolayer versus spheroid cultures of ovarian cancer cells (relates to Figure 4); Supplementary Figure S3. Marker expression in ovarian cancer cell cultures (relates to Figure 4); Supplementary Figure S4. mTORC1 activation potentiates aneuploidy-associated UPR induction, while suppression of mTORC1 by rapamycin causes mild cytostatic effects (relates to Figure 5); Supplementary Figure S5. mTORC1 activation sensitizes to bortezomib in ovarian cancer cells (relates to Figure 5); Supplementary Figure S6. PTEN loss sensitizes to bortezomib in TOV1946 xenografts (relates to Figure 6); Supplementary Table S1. List of primary antibodies; and Supplementary Methods.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362372223