Supplementary Note and Supplementary Figs. 1-8 from Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period
Year: 2023
Type: supplementary-materials
Abstract: SN: Implementation of Deaths from Comorbidities and Failure Rates, Hazard Ratio Calculation & Kaplan Meier Analysis, CRT Model Parameter Calibration, TKI Model Parameter Calibration, Model Validation Against Clinical Trials, Multimodal Target-Chemoradiotherapy Treatment Modeling, Statistical Power Estimation, Robustness of Results to Pre-existing Resistance and Persistence; SF1: Full Parameter Space Analysis of Model Calibration; SF2: Model Simulated PFS for WT and EGFR+ Populations Receiving Concurrent Chemoradiotherapy; SF3: Histograms of Model Parameters for Simulated Population; SF4: Model Predicted Local versus Distant Recurrence Patterns Receiving Sequential Versus Concurrent Chemotherapy; SF5: Model Predictions of Full Multimodal Treatment Design Space; SF6: Table of Outcomes for Complete Multimodal Treatment Design Parameter Space; SF7: Estimated Power of Varying Induction Length on PFS as a Function of Sample Size; SF8: Effect of Pre-existing Resistance and Persistence on Benefit of Shorter Induction
Language: English
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4362376633