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Supplementary Figures from Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2

Year: 2023

Type: supplementary-materials

Abstract: The supplementary figures provide additional data demonstrating that ERG represses RTK-PI3K signaling through direct transcriptional repression of IRS2 across multiple model systems. Additional data is provided showing the biologic role of ERG and PI3K signaling in promoting cell proliferation and migration.

DOI: 10.1158/0008-5472.22426321

Authors: Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick Sullivan, Zeda Zhang, Danielle Choi, Neal Rosen, Charles L. Sawyers, Anuradha Gopalan, Yu Chen, Brett S. Carver

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362379240

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