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Supplementary Figures 1 - 5 from Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors

Year: 2023
Type: supplementary-materials
Abstract: PDF file - 756K, Supplemental Fig 1. EMP and EMMESO mesothelin expression. Supplemental Fig 2. EMMESO flank tumors retain antigen expression in vivo. Supplemental Fig 3. MesoCAR TILs are unable to secrete IL-2 in response to antigen. Supplemental Fig 4. Supplemental IL-2 helps but is not necessary for CAR TIL recovery. Supplemental Fig 5. IFNγ and TNFα secretion by CAR TILs recovers after resting away from tumor.
DOI: 10.1158/1078-0432.22447665
Authors: Edmund K. Moon, Liang-Chuan Wang, Douglas V. Dolfi, Caleph B. Wilson, Raghuveer Ranganathan, Jing Sun, Veena Kapoor, John Scholler, Ellen Puré, Michael C. Milone, Carl H. June, James L. Riley, E. John Wherry, Steven M. Albelda
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
OpenAlex ID: W4362394419
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