Supplementary Figure 4 from A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 137KB, IHC semi-quantification. Semi-quantitative analysis of cleaved caspase-3 histological samples of DLD-1 and SW620 xenograft tumors treated with vehicle or AZD-1152 (A). Evaluation of multiple low field (2.5x) micrographs revealed a statistical significant difference between vehicle- and drug-treated SW620 (p < 0.0001) tumors but not for analogously treated DLD-1 tumors (p = 0.524). Similar analysis of cleaved caspase-3 histological samples of COLO-205 and LIM-2405 treatment cohorts revealed a statistical significant difference between vehicle-treated and combination-treated COLO-205 (p = 0.025) tumors but not for analogously treated LIM-2405 tumors (p = 0.325) (B).
Authors: Matthew R. Hight, Yiu-Yin Cheung, Michael L. Nickels, Eric S. Dawson, Ping Zhao, Samir Saleh, Jason R. Buck, Dewei Tang, M. Kay Washington, Robert J. Coffey, H. Charles Manning
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362394858