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Supplementary Methods from Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Methods - PDF file 94K, The supplementary methods section describes the following: Construction, expression and purification of different EGFRvIII deletion mutants, cloning of variable heavy (VH) and variable light (VL) domains of P588 and D2C7 mAb, surface plasmon resonance, stability assay, and immunohistochemistry of frozen D270MG brain tumor tissue

DOI: 10.1158/1078-0432.22447884

Authors: Vidyalakshmi Chandramohan, Xuhui Bao, Stephen T. Keir, Charles N. Pegram, Scott E. Szafranski, Hailan Piao, Carol J. Wikstrand, Roger E. McLendon, Chien-Tsun Kuan, Ira H. Pastan, Darell D. Bigner

Language: English

Topic: Toxin Mechanisms and Immunotoxins

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361968882

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