Supplementary Figures S1-S7, Table S1 from Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion–Positive Cancer
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figures S1-S7, Table S1. Figure S1 contains the cell survival data and immunoblot data of BaF3-CD74-ROS1 (WT) clones treated with multiple ALK-TKIs. Figure S2 contains the identified ROS1 mutations by ENU mutagenesis. Figure S3 contains the cell survival data and immunoblot data of the recovered Ba/F3-CD74-ROS1 mutant cells treated with crizotinib or ceritinib. Figure S4 contains the IC50 data and immunoblot data of the transformed BaF3 cells with CD74-ROS1 mutantstreated with crizotinib, ceritinib or AP26113. Figure S5 contains the structure of ROS1 kinase domain mapped resistant mutations corresponding to Figure 3D. Figure S6 contains the cell survival data and immunoblot data of the recovered Ba/F3-CD74-ROS1 mutant cells treated with cabozantinib (XL184). Figure S7 contains the IC50 data and immunoblot data of the transformed BaF3 cells with CD74-ROS1 mutants treated with cabozantinib (XL184). Table S1 contains the cell survival data of high throughput inhibitor screening corresponding to Table1.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362395851