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Supplementary Figure 1 from Impact of Tumor Microenvironment and Epithelial Phenotypes on Metabolism in Breast Cancer

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 102K, Glucose metabolism is elevated in basal-like breast cancer with lactate production increasing with stroma presence. Glucose uptake, oxidation, and glycogen synthesis in increased in breast cancer cells (MCF7 and SUM149) when compared to CAFs (LCAF and BCAF) as shown in A. However, SUM149, basal-like breast cancer cells, exhibit higher levels of glucose metabolism than MCF7, luminal cells (A). Lactate production is increased in all coculture conditions regardless of luminal or basal-like epithelial or fibroblast cells (B).

DOI: 10.1158/1078-0432.22451507

Authors: Heather Ann Brauer, Liza Makowski, Katherine A. Hoadley, Patricia Casbas-Hernandez, Lindsay J. Lang, Erick Romàn-Pèrez, Monica D'Arcy, Alex J. Freemerman, Charles M. Perou, Melissa A. Troester

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362396147

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