Supplemental Tables, Figures and Legends from Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer
Year: 2023
Type: supplementary-materials
Abstract: Table S1. Primers for quantitative RT-PCR. Table S2. The list of primers for ChIP detection; CD44 promoter region. Figure S1. Loss of DAB2IP increased clonogenicity and stemness in normal prostate epithelial cells. Figure S2. Loss of DAB2IP increased in vitro invasion and motility in normal prostate epithelial cells. Figure S3. DAB2IP inhibits CD44 expression in human prostate epithelial cell lines. Figure S4. Wnt pathway correlates with CRPC progression. Figure S5. AR inhibitor doesn't affect the expression of CD44. Figure S6. All CD44 variants respond to Wnt inhibitor. Figure S7. Wnt signal regulates CD44 expression and stem cell properties. Figure S8. Wnt signal pathway mediates the expression of CD44. Figure S9. Wnt inhibitors diminish the chemo-resistance of KD cells. Figure S10. Overexpression of CD44 rescues the growth inhibition by LGK974. Figure S11. Synergistic effect of Wnt inhibitors combined with docetaxel on Du145 cells.
Authors: Eun-Jin Yun, Jiancheng Zhou, Chun-Jung Lin, Elizabeth Hernandez, Ladan Fazli, Martin Gleave, Jer-Tsong Hsieh
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361919085