Work

Supplementary Figure 2 from Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma

Year: 2023

Type: supplementary-materials

Abstract: Orthotopic transplantation maintains histological and subtype specific markers. (A) Hierarchical clustering of subtype specific genes expressed in explanted Ptch1 MB and NSC MB tumors from immunocompetent C57BL/6 hosts. (B) Transplanted Ptch1 MB and NSC MB tumors maintained histological hallmarks of original tumors and were stained with antibodies against synaptophysin (a marker historically used for MB), secreted frizzled-related protein (SFRP1, a marker for SHH tumors) and natriuretic peptide receptor C (NPR3, a marker for Group 3 tumors). Scale bars = 20 µm

DOI: 10.1158/1078-0432.22460132

Authors: Christina D. Pham, Catherine Flores, Changlin Yang, Elaine M. Pinheiro, Jennifer H. Yearley, Elias J. Sayour, Yanxin Pei, Colin Moore, Roger E. McLendon, Jianping Huang, John H. Sampson, Robert Wechsler-Reya, Duane A. Mitchell

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362399143

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