Work

Figure S1 from Therapeutic Immune Modulation against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial

Year: 2023

Type: other

Abstract: Supplemental Figure 1. Enrichments of Broad collection of immunological gene signatures in PBMC of SD (patient 002) and PD patients (patients 004 and 008). (A) non-supervised hierarchical clustering of selected gene signatures (FDR < 0,25). Gene names of enriched genesets are publicly available online at MSigDB: http://software.broadinstitute.org/gsea/msigdb/index.jsp. (B) Comparison of genesets enrichment scores between SD and PD patients. Positive values indicate enrichment in SD patient, while negative values - enrichment in PD patients. Enrichments were calculated based on outputs of GSEA analysis. X-axis: [Signal(SD) - Signal(PD)] / Signal(SD), where Signal is enrichment signal strength of geneset in patient 002 with SD response. Y-axis: [NES(SD) - NES(PD)] / NES(SD), where NES(SD) is normalized enrichment score of geneset in patient 002.

DOI: 10.1158/1078-0432.22467477

Authors: Chrisann Kyi, Vladimir Roudko, Rachel Sabado, Yvonne Saenger, William Loging, John Mandeli, Tin Htwe Thin, Deborah Lehrer, Michael Donovan, Marshall Posner, Krzysztof Misiukiewicz, Benjamin Greenbaum, Andres Salazar, Philip Friedlander, Nina Bhardwaj

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362403044

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