Supplementary Material from Phase I Study of the Anti-CD22 Antibody–Drug Conjugate Pinatuzumab Vedotin with/without Rituximab in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure 1. Summary of study enrollment by dose level and disease cohort. All patients were evaluated for safety and anti-tumor activity. Supplementary Table 1. Enrollment. Supplementary Table 2. Treatment-emergent adverse events occurring in at least 10% of patients treated with pinatuzumab vedotin by pooled dose cohorts and histology. Supplementary Table 3. Incidence of treatment-emergent peripheral neuropathy (PN) among patients with prior PN and/or prior vinca alkaloid treatment. Supplementary Figure 2. Cycle 1 and 3 mean ({plus minus} SD) serum/plasma concentration-time curves for total antibody, conjugate (evaluated as acMMAE), and MMAE following 2.4-mg/kg dose per cycle for every three-week cycle of single-agent pinatuzumab vedotin in B-cell lymphoma patients. Supplementary Table 4. Mean (SD) values for selected serum/plasma PK parameters of total antibody, conjugate (evaluated as acMMAE) and unconjugated MMAE following Cycle 1 doses of pinatuzumab vedotin in PK-evaluable CLL patients. Supplementary Table 5. Tabulation of demographic/clinical features for r/r NHL (combined DLBCL and iNHL) patients with and without PFS events.
Authors: Ranjana H. Advani, Daniel Lebovic, Andy Chen, Mark Brunvand, Andre Goy, Julie E. Chang, Ephraim Hochberg, Sreeni Yalamanchili, Robert Kahn, Dan Lu, Priya Agarwal, Randall C. Dere, Hsin-Ju Hsieh, Surai Jones, Yu-Waye Chu, Bruce D. Cheson
Institutions: Stanford Medicine, Georgetown University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361930090