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Supplementary Figure S1 from Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors

Year: 2023

Type: supplementary-materials

Abstract: Comparative analysis of DAXX/ATRX protein expression and ALT in paired primary and metastatic PanNETs. Patient with a PanNET (A) that is characterized by loss of ATRX expression (C) and ALT (E) by telomere-specific FISH. Within 2 years, the patient developed a distant metastasis within a non-regional lymph node (B) that also demonstrates ATRX loss (D) and is ALT-positive (F).

DOI: 10.1158/1078-0432.22468053

Authors: Aatur D. Singhi, Ta-Chiang Liu, Justin L. Roncaioli, Dengfeng Cao, Herbert J. Zeh, Amer H. Zureikat, Allan Tsung, J. Wallis Marsh, Kenneth K. Lee, Melissa E. Hogg, Nathan Bahary, Randall E. Brand, Kevin M. McGrath, Adam Slivka, Kristi L. Cressman, Kimberly Fuhrer, Roderick J. O'Sullivan

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362404441

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