Work

S1 from Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model

Year: 2023

Type: other

Abstract: Supp Figure S1 Figure S1. SRB assay assessing efficacy of free SN-38 and SN38-TOA NP. A, Growth inhibition by SN38-TOA NPs is statistically significant for 4 nM at 72-h (p=0.0002), and 2 nM and 4 nM at 96-h (p<0.0001). B, Growth inhibition by free SN-38 is statistically significant for 2 nM and 4 nM at 72-h (p>0.0001) and 96-h (p>0.0001), and 1 nM at 96-h (p=0.0007). FD = free drug. NP = nanoparticles.

DOI: 10.1158/1078-0432.22469649

Authors: Ferro Nguyen, Ivan Alferiev, Peng Guan, David T. Guerrero, Venkatadri Kolla, Ganesh S. Moorthy, Michael Chorny, Garrett M. Brodeur

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362405295

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