Supplementary Figure S3 from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S3 related to Figure 5A-C. (A) Individual tumor volume changes in FaDu-xenografted mice treated with vehicle, adavosertib (30 mg/kg or 90 mg/kg, daily, p.o.), alisertib (30 mg/kg, daily, p.o.), or the combinations of alisertib with either adavosertib (30 mg/kg) or adavosertib (90 mg/kg). Tumor volume changes of all mice belonged to this study was shown in bottom panel (n = 8-9 per group). Significant differences between the combination and single drug alone are shown. (B) Body weight (g) of mice was monitored twice a week. Humane endpoint was considered when tumor volume reached 1,000 mm3 following IACUC policy. Graphs depict Mean {plus minus} SEM.
Authors: Jong Woo Lee, Janaki Parameswaran, Teresa Sandoval-Schaefer, Kyung Jin Eoh, Dong-hua Yang, Fang Zhu, Ranee Mehra, Roshan Sharma, Stephen G. Gaffney, Elizabeth B. Perry, Jeffrey P. Townsend, Ilya G. Serebriiskii, Erica A. Golemis, Natalia Issaeva, Wendell G. Yarbrough, Ja Seok Koo, Barbara Burtness
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362406536