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Supplementary Figure S1 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas

Year: 2023

Type: supplementary-materials

Abstract: BAP1 knockdown alters the epigenomic profile in uveal melanoma (UM) cells. (A) Western blot of tetracycline-inducible 92.1 and Mel202 shBAP1 UM cells without (-) and with (+) induction by doxycycline. (B) Multidimensional scaling (MDS) plot of the 1000 most variably methylated probes in the BAP1KD cell experiment, comparing the tetracycline-induced BAP1KD cells (BAP1KD, red) to the un-induced BAP1 control cells (BAP1WT, green). (C) Hierarchical clustering dendrogram, using all methylation probes, plotting the induced (BAP1KD) and uninduced (BAP1WT) 92.1 and Mel202 biological replicates.

DOI: 10.1158/1078-0432.22471826

Authors: Matthew G. Field, Jeffim N. Kuznetsov, Parker L. Bussies, Louie Z. Cai, Karam A. Alawa, Christina L. Decatur, Stefan Kurtenbach, J. William Harbour

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362407171

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