Supplementary Figures 1-5 from Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1. Step-by-step user guide for DISARM application â€" Part 1; Supplementary Figure S2. Step-by-step user guide for DISARM web application â€" Part 2; Supplementary Figure S3. Comparison of DISARM-selected candidates from GDSC in cisplatinsensitive and â€"resistant models identifies numerous drugs that are more effective in cisplatinresistant models; Supplementary Figure S4. Cisplatin-resistance in SCLC, both de novo and acquired, is associated with increased expression of RAF-MEK-ERK (MAPK) pathway, a target predicted by DISARM; Supplementary Figure S5. Cisplatin-resistant SCLC models not previously analyzed by DISARM are sensitive to DISARM candidates.
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4362408559