Supplementary Tables 1-2, Supplementary Figures 1-4 from Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Table 1 â€" Effect of varying RT regimen and dose on survival when combined with anti PD-L1 in orthotopic Balb/c mice harboring LY2 tumors; Supplementary Table 2A â€" Effect of varying combinations of RT and dual immune checkpoint on survival in LY2 mice; Supplementary Figure 1 â€" Cibersort analysis of RNAseq data obtained from orthotopic LY2, MOC1 and MOC2 tumors. Supplementary Figure 2 â€" Tumor growth curves for (A) LY2 and (B) MOC2 tumors treated with anti-PD-L1 and anti-TIM-3 alone and in combination with RT; Supplementary Figure 3 â€" Analysis of relative abundance of mRNA transcript levels of genes involved in Treg differentiation and homing and effector T cell function from LY2 tumors harvested 1-week and 3-weeks after initiation of RT and anti-PD-L1 treatment; Supplementary Figure 4 â€" Analysis of patient samples with the Vectra immuno-fluorescence platform. Two patients with similar disease course but different outcomes were selected for analysis of immune cell profile (CD3, CD8, CD4, FoxP3, DAPI).
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362409092