Figure S3 from Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma
Year: 2023
Type: other
Abstract: Somatic mutation signatures identified by exome sequencing in primary canine lung cancers. (A) The distribution of somatic single nucleotide mutation types in their trinucleotide context from tumor/normal exome sequencing of five cPAC cases. (B) The most common mutation signatures based on trinucleotide context and frequency of somatic single nucleotide mutations from tumor/normal exome sequencing of five cPAC cases. COSMIC Signature 1A (C>T substitutions at NpCpG trinucleotides that are associated with age) was present in four cases. COSMIC Signature 2 (C>T and C>G substitutions at TpCpN, associated with APOBEC cytidine deaminase activity) was present in two cases.
Authors: Gwendolen Lorch, Karthigayini Sivaprakasam, Victoria Zismann, Nieves Perdigones, Tania Contente-Cuomo, Alexandra Nazareno, Salvatore Facista, Shukmei Wong, Kevin Drenner, Winnie S. Liang, Joseph M. Amann, Sara L. Sinicropi-Yao, Michael J. Koenig, Krista La Perle, Timothy G. Whitsett, Muhammed Murtaza, Jeffrey M. Trent, David P. Carbone, William P.D. Hendricks
Language: English
Topic: Veterinary Oncology Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362409238