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Supplementary Figure 2 from Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer

Year: 2023

Type: supplementary-materials

Abstract: (Rows 1 & 2) Parametric maps of intratumoral metabolite ratios, including lactate-to-pyruvate, alanine-to-pyruvate, and alanine-to-lactate before (row 1) and after (row 2) LDHi. These data demonstrate an increase in intratumoral pyruvate, a decrease in intratumoral lactate, and an increase in intratumoral alanine after LDHi. All maps were generated from the acquisition highlighted in Figure 2A. [P=pyruvate, L=lactate, A=alanine]

DOI: 10.1158/1078-0432.22476554

Authors: Nicholas R. Perkons, Omar Johnson, Gabrielle Pilla, Enri Profka, Michael Mercadante, Daniel Ackerman, Terence P.F. Gade

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362409492

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