Work

Supplementary Figures 1 - 5 from Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 581K, Breast TICs are enriched in the CD24HiCD49fHi subpopulation (S1); Expression of HER receptors and ligands in breast cancer cell lines (S2); HER2 inhibition reduces the EpCAM- TIC-like subpopulation of SUM149 cells (S3); Breast TICs are enriched in the EPCAM+CD49f+ subpopulation of a triple-negative patient-derived xenograft breast tumor BCA70 (S4); Dual inhibition of HER2 and EGFR targets breast TICs in patient-derived xenograft BCA71 (S5).

DOI: 10.1158/0008-5472.22399382.v1

Authors: Cleo Yi-Fang Lee, Yuan Lin, Scott V. Bratman, Weiguo Feng, Angera H. Kuo, Ferenc A. Scheeren, Jesse M. Engreitz, Sushama Varma, Robert B. West, Maximilian Diehn

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362419423

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