Work

Supplementary Figures 1 - 4 from PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 292K, Supplementary Figure S1. Phenotype of vaccine-induced NY-ESO-1-specific CD4+ T cells. Supplementary Figure S2. Cytokine production, cytotoxic potential and cytolytic capacities of NY-ESO-1-specific CD8+ T cells following immunization in patients with spontaneous TA-specific CD8+ T cell responses before vaccination. Supplementary Figure S3. PD-1 and Tim-3 blockades increase the proliferation of vaccine-inducedNY-ESO-1-specific CD8+ T cells. Supplementary Figure S4. PD-1 and Tim-3 blockades increase the expansion of vaccine-induced cytokine-producing NY-ESO-1-specific CD8+ T cells.

DOI: 10.1158/0008-5472.22402173.v1

Authors: Julien Fourcade, Zhaojun Sun, Ornella Pagliano, Joe-Marc Chauvin, Cindy Sander, Bratislav Janjic, Ahmad A. Tarhini, Hussein A. Tawbi, John M. Kirkwood, Stergios Moschos, Hong Wang, Philippe Guillaume, Immanuel F. Luescher, Arthur Krieg, Ana C. Anderson, Vijay K. Kuchroo, Hassane M. Zarour

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362419832

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