Supplementary Figures 1 - 6 from Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 417K, NT compounds are allosteric inhibitors of the full-length IGF1R, and induce translocation of IRS1 to the cytoplasm (S1); The anti-proliferative effects of the NT inhibitors are maintained long after the inhibitors are washed out (S2); NT157 inhibits IGF2-induced and insulin-induced PKB activation, without inhibiting the autophosphorylation of IR and IGF1R (S3); The NT-induced Ser-phosphorylation occurs in an IGF1-independent manner (S4); NT compounds inhibit human ovarian cancer and hormonerefractory prostate cancer in xenograft models in mice (S5); Combined treatment with NT157 and PLX4032 induces a synergistic cytotoxic effect in 451-Lu melanoma cells, and NT157 reverses the overexpression of IRS1/2 in Vemurafenib-resistant Mel1617-BR cells (S6).
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361873212