Supplementary Figure S6 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Year: 2023
Type: supplementary-materials
Abstract: Segregation of phosphoAKT1-high and MYC-high prostate tumors by genomics and protein expression. (A) SNP arrays (Affymetrix 250K Sty I array) were performed on 59 prostate tumors and 6 normal tissues. The heat map showing inferred copy number profile was generated with DChip version 2010.01. Densitometric values of phosphoAKT1 or MYC protein (relative to β-actin) for each sample are depicted in the top orange/green heat map. The black bars in the color scales represent the cut-off for low and high protein values. (B) Venn diagram showing the intersections between genomic and protein expression data. Twelve and 11 tumors harbored 10q23.31 loss (PTEN locus, orange circle in (A), chromosome 10) and 8q24.3 gain (MYC locus, green circle in (A), chromosome 8), respectively, representing 26% (7/27) of phosphoAKT1-high and 13% (2/15) of MYC-high tumors.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362290220