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Supplementary Figure S2 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

Year: 2023

Type: supplementary-materials

Abstract: Concentration of glycolysis metabolites (A) in genetically engineered RWPE-1 cells and mice, and human prostate tissue samples. Controls (RWPE-EV, WT mice and normal prostate samples) are represented in blue, phosphoAKT1-high samples in orange and MYC-high samples are in green. (B) Diagram and concentration of metabolites of the glycine/sarcosine pathway in WT (blue), MPAKT (orange) and Lo-MYC (green) mice. One-way analysis of variance (ANOVA) followed by Tukey's Multiple Comparison Test was performed using post-normalization metabolite quantities.

DOI: 10.1158/0008-5472.22405982

Authors: Carmen Priolo, Saumyadipta Pyne, Joshua Rose, Erzsébet Ravasz Regan, Giorgia Zadra, Cornelia Photopoulos, Stefano Cacciatore, Denise Schultz, Natalia Scaglia, Jonathan McDunn, Angelo M. De Marzo, Massimo Loda

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362292064

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