Supplementary Figure S6 from Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S6 A) In vitro validation of NR0B1 immunofluorescent assay. Data shows images and quantitation of TC32 control cells or TC32 cells following siRNA silencing of NR0B1. B) ki67 and cleaved caspase 3 staining of Ewing sarcoma xenograft tissue. C) Histology from tumor xenograft showing zone of differentiation of Ewing sarcoma cells into benign fat cells. Alu-ish staining (blue) marks human cells.
Authors: Matt L. Harlow, Nichole Maloney, Joseph Roland, Maria Jose Guillen Navarro, Matthew K. Easton, Susan M. Kitchen-Goosen, Elissa A. Boguslawski, Zachary B. Madaj, Ben K. Johnson, Megan J. Bowman, Maurizio D'Incalci, Mary E. Winn, Lisa Turner, Galen Hostetter, Carlos María Galmarini, Pablo M. Aviles, Patrick J. Grohar
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361875345