Figure S3 from Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas
Year: 2023
Type: other
Abstract: Supplemental Figure 3: Somatic lesions targeting chromatin regulators in ASCP genomes. CNV profiles of flow sorted aneuploid populations from: A) A129 with homozygous deletion of CDKN2A and SMARCA4. The X and Y axes in the CGH plots represent chromosome and log2 ratios for each TNBC. Red shaded areas denote homozygous deletions. B) Somatic mutations KRASG12V and TET1V128F detected in flow sorted 3.6N population from MR02. The sorted 2.0N fraction was used as a patient matched normal control.
Authors: Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham, William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M. Grandgenett, Michael A. Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C. Hernandez, Jennifer L. Leiting, Ronald M. Evans, Tamas Ordog, Mark J. Truty, Mitesh J. Borad, Tannishtha Reya, Daniel D. Von Hoff, Martin E. Fernandez-Zapico, Michael T. Barrett
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362423634