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Supplementary Figures and legends from Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma

Year: 2023

Type: supplementary-materials

Abstract: Contains supplementary figures and tables with corresponding legends. Figure S1: PAK expression and signaling in RMS. Figure S2: Generation of PAK4 knock down stable clones and phenotypic effects on tumorigenicity. Figure S3: Knockdown of PAK4 inhibits tumor growth in vivo. Figure S4: Phenotypic effects of small molecule inhibitors of PAK4. Figure S5: Pharmacological inhibition of PAK4 in vitro attenuating invasion and migration of cells. Figure S6: Target validation and body weight measurement upon treatment. Figure S7: Molecular analysis of PAK4 targeted proteome. Figure S8: Transcriptomic Analysis of KPT-9274 treated RMS tumors indicating immune modulation. Supplementary table 1: Sequence of primers. Supplementary table 2: Patient annotations.

DOI: 10.1158/0008-5472.22426870.v1

Authors: Atreyi Dasgupta, Laura Sierra, Susan V. Tsang, Lyazat Kurenbekova, Tajhal Patel, Kimal Rajapakse, Ryan L. Shuck, Nino Rainusso, Yosef Landesman, Thaddeus Unger, Cristian Coarfa, Jason T. Yustein

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362423700

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