Work

Supplementary Figure 1 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 403K, Cluster IV is linked to the mitotic polo-like kinase pathway. A, The 84 Cluster IV genes were analyzed for pathway enrichment using IPATM. Bars depict significance of enrichment represented by log p values. The line graph shows magnitudes of enrichment represented by ratios. B, Schematic illustration of the mitotic role of the polo-like kinase pathway (From IPATM), with green and red arrows representing responses to estradiol and Runx2, respectively, in the MCF7/Rx2dox cell culture model. Arrows are boxed to indicate Cluster IV genes, which by definition are stimulated by E2 and inhibited by Runx2.

DOI: 10.1158/1078-0432.22444058.v1

Authors: Nyam-Osor Chimge, Sanjeev K. Baniwal, Jingqin Luo, Simon Coetzee, Omar Khalid, Benjamin P. Berman, Debu Tripathy, Matthew J. Ellis, Baruch Frenkel

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362427229

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