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Supplementary Table 3 from Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 48K, RPPA data for the colon and melanoma cell lines. Values are log-base 2, normalized to both total protein loading per sample and the median protein expression. HT29/WiDr, and Colo201/Colo205 are derived from the same patient under different time courses/conditions, and therefore may be provide limited additional data (Semple TU et al., Cancer Res. 1978 May;38(5):1345-55, Chen TR et al Cancer Genet Cytogenet. 1987 Jul;27(1):125-34). Sensitivity analysis demonstrates no change in the conclusions with the inclusion or exclusion of these isogenic cell lines.

DOI: 10.1158/1078-0432.22445814

Authors: Muling Mao, Feng Tian, John M. Mariadason, Chun C. Tsao, Robert Lemos, Farshid Dayyani, Y.N. Vashisht Gopal, Zhi-Qin Jiang, Ignacio I. Wistuba, Xi M. Tang, William G. Bornman, Gideon Bollag, Gordon B. Mills, Garth Powis, Jayesh Desai, Gary E. Gallick, Michael A. Davies, Scott Kopetz

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361881510

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