Work

Supplementary Figure Legends and Figures from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Year: 2023

Type: supplementary-materials

Abstract: PDF file, 3383K, Figure-S1: Missense mutation resulting in alternative splicing and RT-PCR screens for KDR-PDGFRA fusion and PDGFRA ; Figure-S2: Analysis of PDGFR� downstream effectors ; Figure-S3: Mutant PDGFR� is sensitive to small molecule inhibitors ; Figure-S4: Dose-dependent sensitivity to crenolanib ; Figure-S5: Crenolanib and desatinib induce G0/G1 arrest ; Figure-S6: Signaling in PDGFRa-driven HGGs ; Figure-S7: PDGFR�-driven murine HGGs show a range of gene expression signatures.

DOI: 10.1158/0008-5472.22397556.v1

Authors: Barbara S. Paugh, Xiaoyan Zhu, Chunxu Qu, Raelene Endersby, Alexander K. Diaz, Junyuan Zhang, Dorine A. Bax, Diana Carvalho, Rui M. Reis, Arzu Onar-Thomas, Alberto Broniscer, Cynthia Wetmore, Jinghui Zhang, Chris Jones, David W. Ellison, Suzanne J. Baker

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362432188

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