Supplementary Figure S3 from Establishment of Patient-Derived Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response
Year: 2023
Type: supplementary-materials
Abstract: Fig. S3. Recapitulation of transcriptional characteristics of parental tumors and SDH-deficiency by patient-derived mSDH GIST models. A. Scatter Plot of the first two principal components and associated percentage of variance they explain for each SDH-deficient tumor and cell culture, as well as GIST882. B. The normalized gene set activity score (y-axis) for each investigated signature in Figure 3B and 3H, is displayed for each SDH-deficient tumor and cell culture, as well as GIST882. C. mSDH GIST spheroids express higher levels of 5-mC than 5-hmC when compared to GIST882 cells stained with an antibody to 5-mC (red) or to 5-hmC (green) followed by imaging with confocal fluorescence microscopy. Nuclei were stained with DAPI (blue). Scale bar, 50 ï�m.
Authors: Mayra Yebra, Shruti Bhargava, Avi Kumar, Adam M. Burgoyne, Chih-Min Tang, Hyunho Yoon, Sudeep Banerjee, Joseph Aguilera, Thekla Cordes, Vipul Sheth, Sangkyu Noh, Rowan Ustoy, Sam Li, Sunil J. Advani, Christopher L. Corless, Michael C. Heinrich, Razelle Kurzrock, Scott M. Lippman, Paul T. Fanta, Olivier Harismendy, Christian Metallo, Jason K. Sicklick
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362432379