'Supp Fig S1' from Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer
Year: 2023
Type: other
Abstract: 'Representative examples of primary tumors with discordant TP53 sequencing and p53 immunostaining results on tissue microarray. Two tumors with TP53 missense mutations (upper left and upper right) did not show appreciable nuclear accumulation of TP53. Note that the mutation in the tumor on the upper left (p.R282W) was detected in another sample from a different patient by IHC and the tumor on the upper right had 8 separate TP53 missense mutations detected, of unknown significance. Two additional tumors without missense mutations (one WT by sequencing on lower left, and one with an in-frame deletion on lower right) both showed nuclear accumulation of p53 protein by IHC in >10% of cells and were considered false positives. All photomicrographs are reduced from 200x.'
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362432653