Supplementary Figure 4 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 126K, Dual inhibition of Chk1 and Wee1 significantly impairs tumor growth in vivo. Mice were treated with either 30 mg/kg of single agent MK-1775 (targeting Wee1), single-agent MK-8776 (targeting Chk1) or simultaneous MK-1775 and MK-8776. Mixed linear effects model was used to calculate the rate of tumor growth in each condition, and demonstrated that dual inhibition was efficacious in both SKNAS and NB1643 xenograft models. Mice harboring NB1643 xenografts were treated for 48h, tumors were resected and target engagement was validated by western blot analysis
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362461685