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Supplementary Figure 2 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 48K, Wee1 and Chk1 expression are elevated in high-risk, MYCN-amplified neuroblastoma. Primary tumors were obtained from 251 patients at diagnosis (221 high-risk, 30 low-risk; 68 MYCN amplified, 183 MYCN non-amplified), and were run on Affymetrix Human Exon 1.0 ST expression microarrays. Both Wee1 and Chk1 expression were expressed at a significantly higher rate in both the MYCN amplified and high-risk conditions

DOI: 10.1158/0008-5472.22399259.v1

Authors: Mike R. Russell, Kirill Levin, JulieAnn Rader, Lili Belcastro, Yimei Li, Daniel Martinez, Bruce Pawel, Stuart D. Shumway, John M. Maris, Kristina A. Cole

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362461875

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