Supplementary Figures 1 - 7, Table 1 from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 456K, Table S1: Growth inhibition of NCI-60 panel of cancer cell lines by L002 (NSC764414); Supplemental Figure 1: Distribution of hits in the primary potentiator screen ; Supplemental Figure 2: Hit distribution in the primary and counterscreen assays ; Supplemental Figure 3: Fluorescence-based in vitro p300 inhibition assay ; Supplemental Figure 4: Summary of the HTS campaign ; Supplemental Figure 5: L002 does not inhibit HDACs ; Supplemental Figure 6: L002 does not inhibit HMTs ; Supplemental Figure 7: Impacts of L002 and other hits on histone modifications
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362477733