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Supplementary Figures 1 - 3, Tables 1 - 3 from Masitinib Antagonizes ATP-Binding Cassette Subfamily C Member 10–Mediated Paclitaxel Resistance: A Preclinical Study

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 255K, Supplemental Figure 1. The expression of c-Kit and p-c-Kit protein in HEK293/pcDNA3.1 and HEK293/ABCC10 cell lines, respectively. Supplemental Figure 2. The effect of masitinib administration on HEK293/pcDNA3.1 tumor growth in vivo. Supplemental Figure 3. Model of masitinib-mediated sensitization of paclitaxel in tumor cells. Supplemental Table 1. Masitinib significantly sensitizes HEK293/ABCC10 cells to vinblastine and vincristine with no or minimal effect on HEK293/pcDNA3.1 cells. Supplemental Table 2. The effect of reversal drugs on the cytotoxicity of paclitaxel to HEK293/pcDNA3.1 and HEK293/ABCB1 cells. Supplemental Table 3. The effect of reversal drugs on the cytotoxicity of vincristine to HEK293/pcDNA3.1 and HEK293/ABCC1 cells.

DOI: 10.1158/1535-7163.22500468

Authors: Rishil J. Kathawala, Kamlesh Sodani, Kang Chen, Atish Patel, Alaa H. Abuznait, Nagaraju Anreddy, Yue-Li Sun, Amal Kaddoumi, Charles R. Ashby, Zhe-Sheng Chen

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362481558

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Related to: 10