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Supplementary Figure 7. Immunofluorescent localization of Fas and p62. from Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10–Dependent Apoptosis by Carfilzomib and Selinexor

Year: 2023

Type: supplementary-materials

Abstract: MM1.S cells were left untreated or treated with Selinexor and Carfilzomib (CFZ; 50 nm each) overnight. Cells were then processed as described for immunofluorescence microscopy using anti-Fas mouse monoclonal antibody and anti-p62 rabbit polyclonal antibody and appropriate fluorophore-conjugated secondary antibodies. Cell surface Fas does not co-localize with p62-containing aggregates, supporting the notion that caspases and p62 localize to intracellular membranes.

DOI: 10.1158/1535-7163.22503976

Authors: Shaun Rosebeck, Mattina M. Alonge, Malathi Kandarpa, Anoop Mayampurath, Samuel L. Volchenboum, Jagoda Jasielec, Dominik Dytfeld, Sean P. Maxwell, Stephanie J. Kraftson, Dilara McCauley, Sharon Shacham, Michael Kauffman, Andrzej J. Jakubowiak

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362482016

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