Work

Figure S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis

Year: 2023

Type: other

Abstract: Platinum-resistant human epithelial ovarian cancer cell lines OVCAR-5 and OVCAR-4 expresses tyrosyl-DNA phosphodiesterase 1 (Tdp1). The Tdp1 protein expression levels in human epithelial ovarian carcinoma cell lines OVCAR-5 (derived from the ascitic fluid of EOC patient without prior treatment; tumor characterized to be platinum-resistant) and OVCAR-4 (derived from the ascitic fluid of platinum-refractory EOC patient) were evaluated by Western Blot. Tdp1 expression was found higher in the OVCAR-4 cells compared to that in the OVCAR-5 cells.

DOI: 10.1158/1535-7163.22509415

Authors: Huang-Chiao Huang, Joyce Liu, Yan Baglo, Imran Rizvi, Sriram Anbil, Michael Pigula, Tayyaba Hasan

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362482435

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