Work

Supplemental Figures 1-7 from B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Figure 1. Graphical representation of extracellular flux stress profiles from a CLL patient. Supplemental Figure 2. Sorting BCR knockout cells from Cas9 transfected JeKo-1 cells. Supplemental Figure 3. Sorting PIK3CD knockout cells from Cas9 transfected JeKo-1 cells. Supplemental Figure 4. CLL OCR correlation with CD38 expression and age. Supplemental Figure 5. Effect of PI3K inhibitor (IPI-145 or duvelisib) on CLL metabolism. Supplemental Figure 6. Influence of duvelisib (IPI-145) treatment on nutrient uptake mitochondrial biology and functionalities in CLL lymphocytes. Supplemental Figure 7. Effect of AKT inhibitor (MK-2206) on CLL metabolism.

DOI: 10.1158/1541-7786.22515804

Authors: Hima V. Vangapandu, Ondrej Havranek, Mary L. Ayres, Benny Abraham Kaipparettu, Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, R. Eric Davis, Christine M. Stellrecht, Varsha Gandhi

Language: English

Topic: Chronic Lymphocytic Leukemia Research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362483452

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